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KMID : 0613820160260070812
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Journal of Life Science
2016 Volume.26 No. 7 p.812 ~ p.818
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Improvement Effect of Stachys sieboldii MIQ. According to Mixing Ratio of Calcium on Memory Impairment in Scopolamine-induced Dementia Rats
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Choe Da-Jeong
Ahn Hee-Young
Kim Young-Wan
Kim Tae-Hoon
Kim Man-Do
Cho Young-Su
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Abstract
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The aim of this study was to investigate the anti-amnesic effect of Stachys sieboldii MIQ. according to the mixing ratio of calcium on scopolamine-induced learning and memory impairment, in vivo. At the end of the adaptation period, SD rats were divided into a normal group (N), a control group (C: scopolamine), a positive control group (PC: scopolamine + tacrine), and a sample group (S: scopolamine + Stachys sieboldii MIQ., 1CS: scopolamine + low calcium-mixed Stachys sieboldii MIQ., 5CS: scopolamine + high calcium-mixed Stachys sieboldii MIQ.), and were tested with learning and memory tests. The C and CS groups were found to have a decreased scopolamine-induced memory deficit in the Y-maze and water maze tests. Brain tissue analysis showed that the CS group decreased acetylcholinesterase (AChE) activity and increased acetylcholine (Ach) content, both of which are indicative of neuronal cell activity. From a light microscopy study, the nucleus of neurons in the hippocampus of the brain was more shrunken or condensed in the C group compared to the CS group. In the CS group, the damage to the neurons in the hippocampus of the brain was suppressed. These results suggest that Stachys sieboldii MIQ. according to the mixing ratio of calcium provides a significant anti-amnesic effect against scopolamine-induced cholinergic system deficits and cognitive impairment.
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KEYWORD
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Acetylcholine, acetylcholinesterase, dementia, scopolamine, Stachys sieboldii MIQ
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